• Bookkeeping

    Creating a flexible budget Accounting and Accountability

    what is a flexible budget

    With flexible budgets, it’s easy to make updates to revenue and activity figures that haven’t been finalized. Because of these seamless workflows (and because of the inherent adaptability), flexible budgets give way to more efficiency than their fixed budget counterparts. Most flexible budgets use a percentage of projected revenue to account for variable costs rather than assigning a rigid numerical value at the start.

    Pros and Cons of Flexible Budgets

    And because flexible budgets expand and contract in real time, they allow businesses to exist as the organic, growing entities that they are. Instead, the hope is that patterns will be observed making future cost planning easier and more accurate. In addition, a flexible budget can https://thearizonadigest.com/navigating-financial-growth-leveraging-bookkeeping-and-accounting-services-for-startups/ successfully justify increases in costs when compared to actual income. Revenue and cost needs to be compared monthly and adjustments or notes should be made. Additionally, flexible budgets have a lack of accountability to some degree since they are so fluid and open to change.

    • For control purposes, the accountant then compares the budget to actual data.
    • The actual revenue the widget company is taking in has doubled—but the production costs would also go up.
    • With flexible budgets, it’s easy to make updates to revenue and activity figures that haven’t been finalized.
    • The expenses that do not change are the fixed expenses, as shown in Figure 10.25.
    • And if you’d like to create a flexible budget for your organization, Prophix can help.
    • Unlike a static budget, which is based on a fixed level of activity or output, a flexible budget is designed to be adaptable to changes in sales volume, production volume, or other measures of business activity.

    Step Cost Development is Time-Consuming

    what is a flexible budget

    The flexible budget at first appears to be an excellent way to resolve many of the difficulties inherent in a static budget. However, there are also a number of serious issues with it, which we address below. Expenditures may only vary within certain ranges of revenue or other activities; outside of those ranges, a different proportion of expenditures may apply.

    what is a flexible budget

    Insights for next-gen finance leaders

    However, it can also lead to scalability challenges if the sales and customer success teams aren’t able to handle more accounts than were “budgeted” for. A robust flexible budget will have a plan for these scenarios and allocate funds accordingly. Flexible budgets are best used for startups that have a number of variables such as manufacturing, and others that have revenue based on seasonality, as costs are directly impacted by demand. We’ve previously covered the five different types of budget models that businesses can choose from. The flexible budget offers the most customizable experience, allowing it to be easily adopted by many different businesses.

    Benefits of having a flexible budget for your small business

    There were direct variable costs for materials $0.80, labour $1.00, overhead $0.50 and selling and administration $0.50. There were also fixed costs of $25,000 related to the factory and $25,000 related to selling and administration. A fixed budget is one that stays the same and doesn’t change based on variable costs.

    • While flexibility is great, sometimes something unexpected happens that invalidates all the work you did before.
    • Flexible budgets change based on fluctuations with variable costs and have the ability to expand or contract in real time.
    • A flexible budget adjusts for changes in activity levels for all costs, including both fixed and variable costs.
    • Those siloes make flexible budgeting nearly impossible and limit the strategic value of an over-stretched finance team.
    • It also knows that other costs are fixed costs of approximately $40,000 per month.
    • Even if a cost is assigned a numerical value, a monthly review of costs compared to revenue allows that number to be changed for future periods.

    Static versus Flexible Budgets

    Expenses such as rent, management salaries, and marketing costs remain static and do not change based on production. Flexible budgets come with advantages like their usability in variable cost environments, their detailed picture of performance, and their overall efficiency for budgeting teams. But to really fall into strategic finance and budgeting, rather than asking if your budget should be flexible or static, incremental or strategic, you should focus on what line items you can forecast with a flexible method. More than likely, specific sections of your balance sheet or income statements could benefit from a bit more flexibility. If the last few years have taught SaaS companies anything, it’s that sometimes uncertainty is the only certainty there is.

    The 3 Levels of Flexible Budget

    Recent years have illuminated how unpredictable the marketplace can be — making it increasingly challenging to create accurate budgets and execute an effective budget analysis on a recurring basis. Crush complexity, reduce uncertainty, and illuminate data with access to best-in-class automated insights and planning, budgeting, forecasting, reporting, and consolidation functionalities. Prophix is a private company, backed by Hg Capital, a leading investor in software and services businesses.

    Accounts for unforeseen expenses

    Flexible budgets calculate, for example, different levels of expenditure for variable costs. Subsequently, the budget varies, depending on the activity levels that the company experiences. Such a budgeting method is particularly useful for businesses with fluctuating sales cycles, allowing them to align their spending more closely accounting services for startups with their actual income. In Chapter 9, Using budgets to evaluate performance, we discussed the idea of a flexible budget – the restating of our original budget, but using the sales quantities that were actually recorded. The first is the static budget – our original budget – labelled static because it does not move or change.…

  • Artificial intelligence

    How To Make It Easier To Implement AI In Your Business

    7 Key Steps To Implementing AI In Your Business in 2024 Free eBook

    how to implement ai in business

    As a result of that error reducing and higher quality, “AI improves the value prop[osition],” Earley said. AI creates interactions with technology that are easier, more intuitive, more accurate and, thus, better all around, said Mike Mason, chief AI officer with consultancy Thoughtworks. These centers of excellence should include more than just technical experts.

    Unless there are deep pre-existing capabilities, most organizations find it optimal to at least complement internal teams through external partnerships. With the strategy and roadmap defined, deciding the right AI implementation process and methodology is the next key step. Before diving into the details of AI implementation, it’s important to level-set on what exactly artificial intelligence is and the landscape of AI applications. It’s important to keep your entire business informed about the implementation of AI. Although only half of the company may initially use it, it’s crucial that everyone is aware that AI will eventually become a daily tool. Consider informing your clients about using AI to enhance your product or service, depending on the nature of your business.

    how to implement ai in business

    It’s important to narrow a broad opportunity to a practical AI deployment — for example, invoice matching, IoT-based facial recognition, predictive maintenance on legacy systems, or customer buying habits. “Be experimental,” Carey said, “and include as many people [in the process] as you can.” They recognize success metrics evolve quickly, so models require constant tuning. They incentivize data sharing, ideation and governance from the edge rather than just the center. And they never stop incrementally expanding the footprint of experimentation with intelligent systems. Much like traditional software development lifecycles, introducing AI-based capabilities requires upfront planning and phased testing before being ready for full production deployment.

    It requires lots of experience and a particular combination of skills to create algorithms that can teach machines to think, to improve, and to optimize your business workflows. With the help of your managers and leaders of all departments, you can come up with creative ways of using AI tools. And that is your secret ingredient—your staff owning the new process (obviously, managed and supervised by your company’s manager). This collaborative approach can help unlock the full potential of AI in your business. The next step is to test the new processes powered by AI, make the final tweaks and eventually establish service-level agreements (SLAs) for their use.

    Incremental wins can build confidence across the organization and inspire more stakeholders to pursue similar AI implementation experiments from a stronger, more established baseline. “Adjust algorithms and business processes for scaled release,” Gandhi suggested. The successes and failures of early AI projects can help increase understanding across the entire company. “Ensure you keep the humans in the loop to build trust and engage your business and process experts with your data scientists,” Wand said.

    As you begin implementing AI, remember to establish clear SLAs to measure success and ensure a seamless transition into an AI-powered future. “Artificial intelligence is going to be transformative,” yada yada yada, but how do you really approach the problem of implementing AI in business? What about the pitfalls, or the practical steps you need to take to create organizational change? As the CMO of a business automation platform, I’ve witnessed the evolution of intelligent automation and AI firsthand.

    As fast as business moves in this digital age, AI helps it move even faster, said Seth Earley, author of The AI-Powered Enterprise and CEO of Earley Information Science. AI essentially enables shorter cycles and cuts the time it takes to move from one stage to the next — such as from design to commercialization — and that shortened timeline, in turn, delivers better and more immediate ROI. As an example, Kavita Ganesan, an AI adviser, strategist and founder of the consultancy Opinosis Analytics, pointed to one company that used AI to help it sort through the survey responses of its 42,000 employees. Here are 12 advantages the technology brings to organizations across various industry sectors.

    The future will undoubtedly bring unforeseen advances in artificial intelligence. Yet the foundations and frameworks described here will offer durable guidance. With eyes wide open to both profound opportunities and risks, thoughtful adoption of AI promises to shape tomorrow’s data-driven enterprises. The most transformative organizations view AI not as a one-time project but rather as an engine to drive an intelligent, data-driven culture focused on perpetual improvement.

    AI can do a lot, but it can’t run your organization, and you’ll need sophisticated workflows to manage the handoffs and ensure AI and the other aspects of your process are working seamlessly together. Working together, process automation and AI can accomplish much more than they could separately. While AI is a powerful capability that adds value to your data and your employees, it’s not the only thing you need. You’ll need to be able to route a lot of work to and from AI, between it and automation technologies and employees.

    How long does AI implementation take?

    Companies are using AI to improve many aspects of talent management, from streamlining the hiring process to rooting out bias in corporate communications. Moreover, AI-enabled processes not only save companies in hiring costs, but also can affect workforce productivity by successfully sourcing, screening and identifying top-tier candidates. As natural language processing tools have improved, companies are also using chatbots to provide job candidates with a personalized experience and to mentor employees. Additionally, AI tools can gauge employee sentiment, identify and retain high performers, determine equitable pay, and deliver more personalized and engaging workplace experiences with less requirements on boring, repetitive tasks. Predictive analytics use AI-powered tools to analyze data and predict future events.

    how to implement ai in business

    Almost every industry has encountered tools that automate processes, making everyone’s life easier. AI’s monitoring capabilities can be effective in other areas, such as in enterprise cybersecurity operations where large amounts of data need to be analyzed and understood. AI analyzes and learns from data to create highly personalized and customized experiences and services, said Brian Jackson, principal research director at Info-Tech Research Group. There’s great pressure from every direction to bring AI into your enterprise, not least because of the need to keep up with competition and customers. That’s why we interviewed experts to provide advice on where to begin, along with other relevant AI topics like data privacy, trends, and risks.

    AI technologies are quickly maturing as a viable means of enabling and supporting essential business functions. But creating business value from artificial intelligence requires a thoughtful approach that balances people, processes and technology. In the end success requires realistic self-assessment of where existing skills and solutions fall short both now and for the future. AI talent strategy and sourcing lie along a spectrum rather than binary make vs buy decisions.

    Prioritizing speed to impact and flexibility is what enables staying ahead. Beyond machine learning, there are also fields like natural language processing (NLP) focused on understanding human language, and computer vision centered on analysis of visual inputs like images and video. AI continuously proves to be an asset for businesses and has been revolutionizing the way they operate. It goes a long way in helping to cut operational costs, automate and simplify business processes, improve customer communications and secure customer data. When adopting AI in your business, you need to consider the end goals to be achieved and the software programs that will make it easier to reach your ideal customer. An end-first process is important to refine the specific features or capabilities that align with your organization’s goals and to identify the metrics that will be used to determine success.

    Leading technology consulting services and digital transformation partners highlight AI’s incredible value. AI consultants can provide expertise during evaluation, recommendation, and deployment of enterprise-wide AI adoption. However, determining where to start and who to trust to steer your AI initiatives can be an obstacle.

    Customer Service Chatbots

    As a result, businesses can make more informed decisions based on data-driven insights. This can help businesses identify potential risks and opportunities—for example, identifying customers who are likely to churn, which allows companies to take proactive measures to retain these customers. The Appian AI Process Platform includes everything you need to design, automate, and optimize even the most complex processes, from start to finish.

    how to implement ai in business

    Let’s explore the top strategies for making AI work in your organization so you can maximize its potential. They should become a series of scalable solutions but, to become that, you need to build their foundations on high-quality data — while the more data you have, the better your AI will work. Whichever approach seems best, it’s always worth researching existing solutions before taking the plunge with development. If you find a product that serves your needs, then the most cost-effective approach is likely a direct integration.

    Machine learning involves “training” software algorithms with large sets of data, allowing the programs to learn from examples rather than needing explicit programming for every scenario. Artificial intelligence, or AI, refers to software and machines designed to perform tasks that normally require human intelligence. This includes skills like visual perception, speech recognition, decision-making, and language translation. Now that the preliminary stages of AI implementation are completed, the actual implementation of AI comes into play. For this, you need to determine the internal capabilities of your business.

    Expert Advice for How to Incorporate AI Into Your Business

    With a data-driven understanding of the current state through AI readiness assessments, organizations can define a robust strategic plan to guide implementation. Equipped with an understanding of AI’s potential, a clear roadmap to adoption, and insights from those pioneering this technology, your organization will gain confidence in unlocking AI’s possibilities. By journey’s end, you will have the knowledge to make AI a core competitive advantage. Depending on your product, artificial intelligence in business can also be used to automate various processes. For example, e-commerce websites can use AI to optimize product recommendations, translations can be done automatically and AI can help generate new business ideas and even create images for your website. I strongly believe that AI has the potential to transform businesses, and I am enthusiastic about sharing my experience of integrating AI across all levels of our business operations.

    With foundational data, infrastructure, talent and an overarching adoption roadmap established, the hands-on work of embedding machine learning into business processes can begin through well-orchestrated integration. AI is embedding itself into the products and processes of virtually every industry. But implementing AI at scale remains an unresolved, frustrating issue for most organizations.

    During the rollout, make your best effort to minimize disruptions to existing workflows. Engage with key stakeholders, provide training, and offer ongoing support to ensure a successful transition to AI-driven operations. Once your AI model is trained and tested, you can integrate it into your business operations. You may need to make changes to your existing systems and processes to incorporate the AI. As you explore your objectives, don’t lose sight of value drivers (like increased value for your customers or improved employee productivity), as much as better business results. And consider if machines in place of people could better handle specific time-consuming tasks.

    Then, with a few wins behind you, roll out the solution strategically and with full stakeholder support. Artificial Intelligence is playing an ever more important role in business. Every year, we see a fresh batch of executives implement AI-based solutions across both products and processes. And if you were to try the same, would you know how to achieve the best results? By the end of this article, you will — you’ll see precisely how you can use AI to benefit your entire operation.

    how to implement ai in business

    Executives can use AI for business model expansion, experts said, noting that organizations are seeing new opportunities as they deploy data, analytics and intelligence into the enterprise. Efficiency and productivity gains are two other big benefits that organizations get from using AI, said Adnan Masood, chief AI architect at UST, a digital transformation solutions company. As organizations increase their use of artificial intelligence technologies within their operations, they’re reaping tangible benefits that are expected to deliver significant financial value. If you have any doubts, you may simply choose to outsource your AI development to an agency specialized in big data, AI, and machine learning.

    A steering committee vested in the outcome and representing the firm’s primary functional areas should be established, she added. Instituting organizational change management techniques to encourage data literacy and trust among stakeholders can go a long way toward overcoming human challenges. This definitive guide to AI-as-a-Service (AIaaS) explains how businesses of all sizes can now leverage enterprise-grade AI capabilities without massive investments. I am Volodymyr Zhukov, a Ukraine-born serial entrepreneur, consultant, and advisor specializing in a wide array of advanced technologies. My expertise includes AI/ML, Crypto and NFT markets, Blockchain development, AR/VR, Web3, Metaverses, Online Education startups, CRM, and ERP system development, among others.

    Proactive and continuous training is key to unlocking potential and benefit from implementing AI. Scripting integration touch points up front is vital for smooth AI implementation in your company. AI is still a relatively new technology, so don’t be afraid to experiment and try new approaches to see what works best for your business.

    Better quality and reduction of human error

    This can help businesses identify potential fraud in real time and protect themselves from financial losses and reputational damage. Intelligent document processing (IDP) is the automation of document-based workflows using AI technologies. We see a lot of our clients use these tools for things like invoice processing, data entry and contract management, which allows them to save time and resources. What is interesting about AI is that all these models are scripts or pieces of code humans have been training for years. With this new era of AI, there is much more that businesses can do to benefit their internal operations and final customers. Focus on business areas with high variability and significant payoff, said Suketu Gandhi, a partner at digital transformation consultancy Kearney.

    AI Implementation In Business: Lessons From Diverse Industries – Forbes

    AI Implementation In Business: Lessons From Diverse Industries.

    Posted: Fri, 22 Mar 2024 11:30:00 GMT [source]

    Once you have a clear understanding of your business goals, you can align them with the potential benefits of AI so you can have a successful implementation. To prevent security issues when implementing AI, intelligent automation and any new emerging systems think of this like the first time you browsed the internet. Once the overall system is in place, business teams need to identify opportunities for continuous  improvement in AI models and processes. AI models can degrade over time or in response to rapid changes caused by disruptions such as the COVID-19 pandemic. Teams also need to monitor feedback and resistance to an AI deployment from employees, customers and partners.

    Address Security and Privacy

    This article examines automation vs AI, early automation examples, present uses in manufacturing/healthcare/finance, workforce/job considerations, human-AI collaboration opportunities. Rotate department leaders through immersive experiences to motivate spreading capabilities wider and deeper. Centralize access to reusable libraries of pretrained models, frameworks and pipelines. Evaluating fit-for-purpose along both technical and business dimensions is key before committing long-term.

    This guide offers best practices for AI implementation planning, illuminating key steps to integrate AI seamlessly. We will explore critical factors in selecting AI solutions and providers to mitigate risk and accelerate returns on your AI investments. It’s important to remember that, as companies find ways to use AI for competitive advantage, they’re also grappling with challenges. Concerns include AI bias, government regulation of AI, management of the data required for machine learning projects and talent shortages. In addition, financial gains can be elusive if the talent and infrastructure for implementing AI aren’t in place.

    Ok… so now you know the difference between artificial intelligence and machine learning — it’s time to answer two related questions before we dive into actual implementation. One of the benefits of sales forecasting is that it can help businesses to identify potential sales opportunities. Companies can identify areas to increase sales and improve revenue by analyzing sales data and market trends. Sales forecasting can also help businesses optimize their inventory management. By predicting future sales trends, companies can ensure they have the right products in stock to meet demand.

    AI agencies not only have the knowledge and experience to maximize your chance for success, but they also have a process that could help avoid any mistakes, both in planning and production. AI is already helping thousands of businesses and customers with daily transactions. I recommend starting small and fast so you can understand the logistics behind the technology without higher risks and make sure the company you are dealing with has trusted security standards and certifications in place. Once use cases are identified and prioritized, business teams need to map out how these applications align with their company’s existing technology and human resources. Education and training can help bridge the technical skills gap internally while corporate partners can facilitate on-the-job training.

    Early implementation of AI isn’t necessarily a perfect science and might need to be experimental at first — beginning with a hypothesis, followed by testing and measuring results. Early ideas will likely be flawed, so an exploratory approach to deploying AI that’s taken incrementally is likely to produce better results than a big bang approach. However, technical feasibility alone does not guarantee effective adoption or positive ROI. Continually expose more staff to basics of data concepts, analytics tools, and AI interpretability. Shift from always custom building to remixing and fine-tuning existing components. Reward sharing of insights unlocked, not just utilization of existing reports.

    In addition to the regulatory landscape, organizations must identify other hurdles that could get in the way of incorporating AI into the business. Then, once you’ve initially selected an AI use case, ensure you’re working in tandem with your legal and security or risk teams. We’ll begin to answer these questions with tips from AI experts we interviewed (you can find the rest of their insight in the 2024 AI Outlook). But before getting into their advice, we have to cover two important aspects that are foundational to a winning implementation of AI. You can progress to seeing how well your AI performs against a new dataset and then start to put your AI to work on information you’ve never used before.

    • But before getting into their advice, we have to cover two important aspects that are foundational to a winning implementation of AI.
    • Once you’ve integrated the AI model, you’ll need to regularly monitor its performance to ensure it is working correctly and delivering expected outcomes.
    • Sales forecasting can also help businesses optimize their inventory management.
    • Unless there are deep pre-existing capabilities, most organizations find it optimal to at least complement internal teams through external partnerships.

    Regularly reassess your data strategy and make adjustments to your AI solution so you can continue to deliver value and drive growth. Be prepared to make adjustments and improvements to your AI model as your business needs evolve. Stay informed about advancements in AI technologies and methodologies, and consider how they can be applied to your organization. If you want to ensure this solution is for you, download our free step-by-step guide on how to implement AI in your company.

    One of the benefits of chatbots is that they can provide 24/7 customer support, which can help businesses improve their customer service experience and reduce response times. By automating repetitive tasks such as answering FAQs, chatbots can also help businesses reduce the workload on their customer service teams by freeing up agents to focus on more complex tasks. This comprehensive guide aims to empower organizations and show them how to successfully implement AI into their business.

    Take a step-by-step tour through the entire Artificial Intelligence implementation process, learning how to get the best results. This can help businesses better plan their operations and allocate resources more effectively. “The harder challenges are the human ones, which has always been the case with technology,” Wand said. Learn how RAG enhances accuracy, efficiency & cost savings for legal teams, and discover its applications, benefits & considerations for the future of AI in law.

    You can foun additiona information about ai customer service and artificial intelligence and NLP. Organizations can expect a reduction of errors and stronger adherence to established standards when they add AI technologies to processes. Assembling a skilled and diverse AI team is essential for successful AI implementation. Depending on the scope and complexity of your AI projects, your team may include data scientists, machine learning engineers, data engineers, and domain experts. There are a wide variety of AI solutions on the market — including chatbots, natural language process, machine learning, and deep learning — so choosing the right one for your organization is essential. Consider using AI to automate repetitive or time-consuming tasks, improve decision-making, increase accuracy, or enhance customer experiences.

    This means checking for biases in the content, having the team review generated content instead of copy-pasting and avoiding mistakes in the automated process. Remember that AI is a tool that should augment human efforts, not replace them. Therefore, it’s vital to review all tasks, maintain authentic content and still conduct the necessary research. AI can significantly improve business performance by enhancing speed and quality. AI not only works at a scale beyond human capacity, Masood noted, but it removes time-consuming manual tasks from workers — a productivity gain that lets workers perform higher-level tasks that only humans can do. He pointed to the use of AI in software development as a case in point, highlighting the fact that AI can create test data to check code, freeing up developers to focus on more engaging work.

    In fact, continuous improvement is the key to maintaining a competitive advantage in your business. Establish key performance indicators (KPIs) that align with your business objectives, so you can measure the impact of AI on your organization. Regularly analyze the results, identifying challenges and areas for potential improvement. As the world continues to embrace the transformative power of artificial intelligence, businesses of all sizes must find ways to effectively integrate this technology into their daily operations. Then, with the support and experience of a domain specialist, you can put your ideas to work and create long-term value using the demanding field that is artificial intelligence. Start with a small sample dataset and use artificial intelligence to prove the value that lies within.

    Step 6: Prepare your data

    Once you have chosen the right AI solution and collected the data, it’s time to train your AI model. This involves providing the model with a large, comprehensive dataset so the model can learn patterns and make informed predictions. Start by researching different AI technologies and platforms, and evaluate each one based on factors like scalability, flexibility, and ease of integration. Assess each vendor’s reputation and support offerings, and find out if the solution is compatible with your existing infrastructure. But successfully implementing AI can be a challenging task that requires strategic planning, adequate resources, and a commitment to innovation.

    The world’s most innovative organizations trust Appian to improve their workflows, unify data, and optimize operations—resulting in better growth and superior customer experiences. Customer service chatbots—AI-powered tools that can help businesses improve their customer service experience—interact with customers using natural language, answering their questions and resolving their issues in real time. It is believed to have the potential to make a transformation in any industry and offer a promising future for businesses with its learning algorithms. The global technology intelligence organization ABI Research predicts the number of businesses that will adopt AI worldwide will scale up to 900,000 this year, with a compound annual growth rate of 162%. This revolutionary technology helps improve customer decision management, forecasting, QA manufacturing and writing software code, increasing revenue with the data it generates every day. Businesses can also use IDP to gain insights from large volumes of documents.

    As in all new initiatives, creating an environment where teams can fail fast breeds more creativity and enables quicker progress. Not doing so can lead to wasted resources, delayed priorities, and, sometimes, outright failure. Roboyo’s Chief Technical Officer, Frank Schikora, advises mapping AI to clear value for the business. Once you’ve integrated the AI model, you’ll need to regularly monitor its performance https://chat.openai.com/ to ensure it is working correctly and delivering expected outcomes. Once you have your data prepared, remember to keep it secure, but beware… standard security measures — like encryption, anti-malware apps, or a VPN — may not be enough, so invest in robust security infrastructure. Only once you understand this difference can you know which technology to use — so, we’ve given you a little head start below.

    • “Artificial intelligence is going to be transformative,” yada yada yada, but how do you really approach the problem of implementing AI in business?
    • AI analyzes and learns from data to create highly personalized and customized experiences and services, said Brian Jackson, principal research director at Info-Tech Research Group.
    • If you have any doubts, you may simply choose to outsource your AI development to an agency specialized in big data, AI, and machine learning.
    • These models of AI are customizable to a business as long as you find the right product or service company in the market.
    • And they never stop incrementally expanding the footprint of experimentation with intelligent systems.

    By doing so, we can all gain a better understanding of the value of AI and how it can revolutionize our workforce. Recently, I have been particularly fascinated by the development of AI technology in the business world, especially with the advent of content writing tools and chatbots powered by ChatGPT. Chat PG As such, I have made it my mission to educate my colleagues about these tools and encourage them to incorporate them into their daily operations. From the start of agriculture over 10,000 years ago to the digital revolution, the human race has always been looking for ways to make tasks more efficient.

    We will demystify artificial intelligence, assess your readiness to adopt it, develop a robust AI strategy, choose the right implementation approach, integrate AI across operations, and ultimately, embrace continuous AI innovation. With the right framework in place, AI can help automate mundane tasks, uncover actionable insights, and take your organization into the future. I have been in the BPO industry for over a decade, exploring tools for marketing, CRMs, bookkeeping, CMS, e-commerce, etc., to improve business processes and performance. Through my experience, I have gained a deep appreciation for the benefits of these tools, and I am always looking for ways to incorporate new technology to improve our operations.

    Businesses can help ensure success of their AI efforts by scaling teams, processes, and tools in an integrated, cohesive manner. There are many potential downfalls to consider when implementing intelligent automation and AI. The security aspect of AI has been the primary concern among the business community. The overall process of creating momentum for an AI deployment begins with achieving small victories, Carey reasoned.

    As we explore how to implement AI capabilities into an organization, having clarity on the AI landscape is an indispensable starting point upon which to build a strategy and roadmap. Both the pace of advancement and variety of applications continue to expand rapidly – understanding this larger context ensures efforts stay targeted and future-proofed. When it comes to integrating AI into a business, there are several challenges to navigate.

    With natural language processing (NLP), companies can analyze the content of documents to identify patterns, trends and anomalies, which can help with making better data-driven decisions. Artificial intelligence (AI) has become essential for businesses to streamline operations and improve overall efficiency. AI-powered tools can help companies automate time-consuming tasks, gain insights from vast data and make informed decisions.

    how to implement ai in business

    The answers to these questions will help you to define your business needs, then step towards the best solution for your company. Monitoring thousands of transactions simultaneously can become problematic if you don’t have the proper structure. These models of AI are customizable to a business as long as you find the right product or service company in the market.

    Blending the strengths of productized solutions with expert guidance tailored to your use cases provides an advantageous balance of control, agility and capability development. Informing stakeholders and aligning executive leaders around specific transformative use-cases is vital to driving urgency, investment, and AI implementation in your company. As workers at all levels become more comfortable and confident working with AI, experts said they’re starting to use AI tools to help them be more creative and more innovative. Before diving into the world of AI, identify your organization’s specific needs and objectives. If you already have a highly-skilled developer team, then just maybe they can build your AI project off their own back. Regardless, it could help to consult with domain specialists before they start.

    Begin by implementing AI in a specific area or department and gradually expand to other sites as you gain more experience. The first thing you need to do is overcome the skepticism of those who don’t believe in this new technology. If you don’t show how useful AI can be, your teams won’t show how to implement ai in business interest in using it. So show them the tools you’ve found and allow them time to experiment with it. Only then might you see the spark in their eyes when they realize the possibilities of use. “The AI understands an unstructured query, and it understands unstructured data,” Mason explained.

    The right AI software should allow easy deployment due to its flexible architecture. Using this software, you should be able to uncover the power of data in your business with advanced predictive modeling applications and to make use of data flow graphs for building the data models. Be prepared to work with data scientists and AI experts to develop and fine-tune your model so it can deliver accurate and reliable results that align with your business objectives.

    Carefully orchestrating proof of concepts into pilots, and pilots into production systems allows accumulating experience. However the real breakthrough comes from ultimately fostering a culture hungry to incorporate predictive intelligence into daily decisions and workflows. The playbook detailed here serves as guideposts for structuring and sequencing this transformation – but realizing the full value requires pushing AI implementation steps from an agenda item to a cultural cornerstone. Enable teams closest to your customers to specify enhancement opportunities or new applications of AI. After the AI program becomes operational, now is the time to test the system to see how your efforts are helping reach your goals. When you know your metrics, such as order times, sales improvement and productivity, you can decide how to best implement AI in your business.

    Teams comprising business stakeholders who have technology and data expertise should use metrics to measure the effect of an AI implementation on the organization and its people. Forrester Research further reported that the gap between recognizing the importance of insights and actually applying them is largely due to a lack of the advanced analytics skills necessary to drive business outcomes. “Executive understanding and support,” Wand noted, “will be required to understand this maturation process and drive sustained change.” Success requires grounding in clear business objectives, organizational readiness for emerging technologies, and high-quality data. Strategy must align diverse stakeholders to balance short-term returns with long-term investments into infrastructure, while still moving aggressively. Constructing an effective AI implementation strategy requires aligning on vision, governance, resourcing, and sequencing to ensure efforts stay targeted on business priorities rather than just chasing technology trends.…

  • Bootcamp de programación

    Análisis de Datos: ¿Qué es, para qué sirve y qué tipos hay?

    Además de las funciones básicas, Excel también ofrece herramientas gráficas que te permiten visualizar tus datos de manera efectiva. Puedes crear gráficos de barras, gráficos de líneas, gráficos circulares y muchos otros tipos de gráficos para representar tus datos de manera clara y concisa. Una vez que tengas una base sólida en estadística, podrás aplicar esos conocimientos en Excel. La herramienta ofrece una amplia gama de funciones estadísticas que te permiten realizar análisis avanzados de tus datos.

    ¿Qué es el análisis de datos? (Con ejemplos)

    En QuestionPro contamos con una herramienta de análisis de datos precisa que te ayudará a tomar mejores decisiones de forma profesional. Todo depende mucho del management de cada empresa y de las decisiones que se quieran tomar, del tamaño de la compañía y del rubro. No obstante, la realidad ha demostrado que curso de análisis de datos tener profesionales en analítica y ciencia de datos es indispensable para aumentar los niveles de captación y procesamiento de datos. A pesar de que los softwares de análisis son potentes y confiables, los demás procesos que involucra la inteligencia de negocios sigue siendo una habilidad de la mente humana.

    Ventajas de realizar un análisis estadístico

    para que sirve el analisis de datos

    Los datos se limpian, enriquecen y transforman para que actúen como “fuente única de verdad” en la que los usuarios puedan confiar. Algunos ejemplos de datos son los perfiles de los clientes y la información sobre los productos. En el análisis estadístico te dedicarás a explorar, recopilar y presentar grandes cantidades de datos e información a fin de descubrir tendencias y patrones. La estadística es algo que se aplica todos los días en todos los aspectos, como la industria, los gobiernos y las investigaciones. Los tipos de análisis de datos poseen diversas técnicas que pueden serte muy útiles dependiendo de las necesidades de tu investigación. El análisis de datos estadístico es un modelo de procesamiento para grandes cantidades de información cuantificable.

    ¿Qué es el análisis de datos en estadística y cómo se aplica?

    Pues bien, teniendo en cuenta que los clientes conocen a la empresa a través de la web (lugar en el que también compran) lo primero sería medir los ingresos de los navegantes en la tienda e-commerce. Entonces, el especialista puede observar, https://elobservadortrujillo.com/entrar-en-el-mundo-de-los-datos-con-el-bootcamp-de-tripleten-para-ganar-un-salario-por-encima-del-promedio/ por ejemplo, que la mayoría de los usuarios abandonan la página desde un primer momento. Al incorporar un profesional especializado en la Data Science, lo que se logra es tener una previsión sobre lo que puede llegar a ocurrir.

    • De la misma manera, la importancia del análisis de información a escala empresarial también cobra especial relevancia a la hora de evitar crisis.
    • La estadística es algo que se aplica todos los días en todos los aspectos, como la industria, los gobiernos y las investigaciones.
    • La ashwagandha también podría interactuar con los medicamentos para la diabetes y la presión arterial, los sedantes, y los fármacos que suprimen el sistema inmunitario.
    • Así, unificas toda tu base de datos (de tus sistemas principales y complementarios) en una única plataforma, centralizando los diferentes tipos de análisis y contando con recursos innovadores.
    • Con el histograma logramos verificar que la distribución es normal (es decir que tiene forma como de campana, como por ejemplo la edad) o si está sesgada.

    ejemplos de análisis para la toma de decisiones

    • Hasta el instante hemos visto el análisis y visualización de una sola variable, lo que se conoce necesariamente como análisis univariado.
    • Algunos ejemplos de datos son los perfiles de los clientes y la información sobre los productos.
    • Empezó a atacarla (a Sheinbaum) con el tema de ‘narcocandidata’, pero debió haber sido más clara”, destacó.

    Cuando se logra, los resultados obtenidos representan una verdadera contribución a la solución de los problemas inherentes al campo donde se desarrollan las actividades propias de las diferentes investigaciones. La mayoría de las organizaciones manejan ciertos grados de independencia en relación con https://diarioshoy.com/mexico/entrar-en-el-mundo-de-los-datos-con-el-bootcamp-de-tripleten-para-ganar-un-salario-por-encima-del-promedio/ sus trabajadores. Por ejemplo, puede que los primeros quieran encarar una campaña que se salga del presupuesto que indican los segundos, aunque en marketing creen que esa inversión está justificada. Recibe en tu correo electrónico los últimos consejos para mejorar tu estrategia de marketing.

    para que sirve el analisis de datos

    • Solo tienes que incluir un análisis de datos, exploratorio o estadístico, que lo sustente.
    • La matriz de análisis de datos es una herramienta que se utiliza en el proceso de análisis de datos para organizar y estructurar la información de manera visual y sistemática.
    • Estas dos cifras nos demuestran la importancia que los profesionales en analítica y ciencia de datos tienen hoy en día.
    • Algunos ejemplos de datos son el contenido de las redes sociales, los datos de los dispositivos IoT y los datos no relacionales de las aplicaciones móviles.
  • General

    Activate

    Activate – Pikirkan pria paling menarik yang Anda kenal.

    Sekarang bayangkan seperti apa dia jika dia dibesarkan di gubuk terpal tanpa pipa ledeng dalam ruangan, di sebuah kota kecil bernama Dowagiac Michigan, yang berjarak sekitar 20 mil di utara Universitas Notre Dame.

    Bayangkan jika dia bergabung dengan biara, memiliki karir yang luas sebagai model wanita, aktris, penulis dan penulis skenario, kemudian menukar tenun dan kuku akriliknya untuk gelar Ph.D. dalam ilmu saraf.

    Jika Anda sudah bisa menyulap gambar itu, ubah menjadi 11, lalu perkenalkan diri Anda kepada Dr. Billi Gordon.

    Hari-hari ini, Dr. Gordon menghabiskan sebagian besar waktunya melakukan penelitian menggunakan pencitraan resonansi magnetik fungsional (fMRI) untuk mengidentifikasi dasar neurologis perilaku.

    Secara khusus, ia mempelajari patofisiologi stres sebagai anteseden penyakit.

    Penelitiannya didorong oleh keinginan untuk meningkatkan kesadaran dan membuat dunia yang lebih ramah dan menyehatkan.

    Pendidikan

    Dr. Gordon lulus dengan pujian dari University of Michigan, Ann Arbor pada tahun 1997, di bawah bimbingan Dr. Sandra Cole, Profesor, Fakultas Kedokteran Universitas Michigan.

    Ia lulus dengan predikat summa cum laude dengan gelar Magister Interdisipliner dalam Psikologi dan Sosiologi di California State University di Northridge, di bawah arahan Dr. James Elias, peneliti aktif terakhir dari Kinsey Institute asli, Direktur Pusat Penelitian Seks, dan Ahli Pilihan Kesaksian oleh Mahkamah Agung Amerika Serikat dalam Masalah Seksualitas Manusia.

    Pada bulan November 2004, setelah menyelesaikan magang 3 tahun di Brain Mapping Core dari Pusat Ilmu Neurovisceral dan Kesehatan Wanita di Departemen Penyakit Pencernaan di Sekolah Kedokteran David Geffen di UCLA, Gordon dianugerahi gelar Ph.D. D dalam Ilmu Saraf. dr. Gordon melakukan Penelitian Pasca Doktoral di Sekolah Kedokteran David Geffen di UCLA di bawah pengawasan Mark S. Cohen PhD, dalam Penelitian Otak dan Neuroimaging Fungsional di Pusat Pemetaan Otak UCLA. Selama waktu ini, Dr. Gordon bertugas di Komite Advokasi Masyarakat Sarjana Pasca Doktoral UCLA.

    Profesional

    Dr Gordon saat ini menjabat sebagai Ketua Komite Penasehat untuk Keprihatinan Kolektif dalam Kedokteran.

    Dia adalah anggota SAG-AFTRA dan Writer’s Guild of America, PEN-USA, dan telah menulis Empat Buku.

    Pribadi

    Pada tahun 1981, ketika ayah Dr. Gordon meninggal tiba-tiba, dia memindahkan ibunya yang cacat mental ke rumahnya dan merawatnya sampai kematiannya pada tahun 2002.

    Pada tahun 1988, (selama fase transgendernya) Negara Bagian California mengeluarkan Dr. Gordon dan laki-lakinya pasangan surat nikah, dan mereka menikah di Watsonville, CA pada bulan Agustus tahun itu, dan masih menikah hari ini.…

  • General

    Free Speech Central

    Free Speech Central – Kongres tidak akan membuat undang-undang yang menghormati pendirian agama, atau melarang pelaksanaannya secara bebas; atau meringkas kebebasan berbicara, atau kebebasan pers; atau hak rakyat untuk berkumpul secara damai, dan untuk mengajukan petisi kepada pemerintah untuk ganti rugi.- Konstitusi Amerika Serikat.

    Kami adalah kelompok blogger yang beragam, yang seperti Amerika melampaui semua garis, ras, etnis, pendidikan, dan ekonomi.

    Benang merah kami adalah bahwa kami percaya pada kebutuhan untuk berbicara kami untuk dunia yang lebih baik, lebih menyehatkan daripada yang kita kenal.

    Kami membawa berbagai pesan. Di sini, untuk menghormati Amandemen Pertama Konstitusi Amerika Serikat.

    Selamat datang di Free Speech Central; selamat datang di Amerika George Washington dan Thomas Jefferson.

    Nikmati masa tinggal Anda, komentar dari hati Anda, ini adalah zona bebas penilaian.…

  • Berita Kesehatan 2021: Perbedaan Dosis Obat Pada Pasien
    Billygordon

    Berita Kesehatan 2021: Perbedaan Dosis Obat Pada Pasien

    Berita Kesehatan 2021: Perbedaan Dosis Obat Pada Pasien – Kenyataan yang dialami oleh terlalu banyak orang kulit hitam di Amerika Serikat adalah bahwa mereka menerima lebih sedikit bantuan dalam mengelola rasa sakit dari profesional kesehatan daripada pasien kulit putih.

    Meskipun ketidaksetaraan rasial ini telah ditunjukkan secara konsisten, sumber di balik perbedaan ini belum diidentifikasi. sbobetonline

    Sebuah studi baru membandingkan resep obat penghilang rasa sakit di antara pasien kulit hitam dan kulit putih di AS di seluruh dan di dalam sistem kesehatan individu, dan mengungkap perbedaan ini.

    Berita Kesehatan 2021: Perbedaan Dosis Obat Pada Pasien

    Sistem medis A.S. memberikan lebih sedikit penghilang rasa sakit untuk pasien kulit hitam daripada pasien kulit putih, dan ini telah terjadi selama beberapa dekade.

    Lebih banyak pasien kulit hitam dilayani oleh sistem perawatan kesehatan berkualitas lebih rendah, dan selama bertahun-tahun, para peneliti telah berhipotesis bahwa ini adalah penyebab ketidakadilan pereda nyeri.

    Sebuah studi baru dari para peneliti di Dartmouth College di Hanover, New Hampshire, bagaimanapun, menunjukkan masalahnya ada di tempat lain.

    Studi ini menemukan bahwa pasien kulit hitam dan kulit putih menerima jumlah resep penghilang rasa sakit yang sama, tetapi dokter secara rutin meresepkan dosis yang jauh lebih rendah untuk pasien kulit hitam.

    “Temuan kami kemungkinan mencerminkan bias rasial sistematis selama perawatan yang mengarah pada penerimaan obat nyeri,” kata penulis utama studi tersebut, Nancy Morden.

    Dr. Morden menambahkan, “Kami berharap pelaporan tingkat sistem kami akan mendorong dialog dan komitmen untuk eksplorasi mendalam tentang ketidakadilan ini — penyebabnya, konsekuensinya, dan pengujian tanpa lelah atas potensi perbaikan.”

    Studi baru ini diterbitkan dalam New England Journal of Medicine.

    Dr Tiffany Green, yang bukan salah satu penulis penelitian baru, mengatakan kepada Medical News Today bahwa penelitian ini sejalan dengan penelitian terpisah mengenai pasien yang telah menjalani kelahiran sesar.

    Dr. Green, dari departemen ilmu kesehatan populasi dan kebidanan & ginekologi di University of Wisconsin-Madison, adalah penulis senior dari sebuah penelitian yang dipresentasikan pada Konferensi Masyarakat untuk Kedokteran Janin Maternal 2020.

    Dr. Green dan timnya menemukan bahwa, “Pasien kulit hitam melaporkan tingkat nyeri rata-rata yang lebih tinggi dibandingkan pasien kulit putih, tetapi masih menerima jumlah obat nyeri yang sama.”

    Mengontrol skor nyeri yang dilaporkan, jelas Dr. Green, mereka menerima lebih sedikit obat penghilang rasa sakit daripada rekan kulit putih mereka. Hal ini juga terjadi pada pasien Asia.

    310 sistem kesehatan dianalisis

    Para peneliti menganalisis resep obat nyeri dari 310 sistem kesehatan yang memberikan perawatan primer kepada pasien kulit hitam dan putih.

    Mereka menemukan bahwa, secara keseluruhan, pasien kulit hitam dan putih memiliki kemungkinan yang sama untuk diberikan resep penghilang rasa sakit.

    Perbedaannya terletak pada dosis yang ditentukan.

    Dalam 90% dari sistem perawatan kesehatan yang dipantau dalam penelitian ini, pasien kulit putih menerima dosis yang lebih tinggi setiap tahun daripada pasien kulit hitam.

    Di sebagian besar sistem ini, perbedaan kekuatan resep adalah 15% atau lebih besar.

    Faktor di balik perbedaan

    “‘Mengapa’ adalah pertanyaan jutaan dolar,” kata Dr. Green.

    “Saya pikir,” lanjutnya, “banyak dokter ingin percaya bahwa mereka egaliter dan objektif, tetapi data menunjukkan bahwa mereka memiliki jenis bias anti-Kulit Hitam yang sama dengan orang-orang pada populasi umum.”

    Dr Vickie M. Mays, yang tidak terlibat dalam penelitian ini, berbicara dengan Medical News Today.

    Meskipun tidak meminimalkan peran bias rasial pribadi, Dr. Mays, dari departemen psikologi UCLA di College of Life Sciences, mengingat bahwa penelitian beberapa tahun yang lalu mengungkapkan betapa besar bias sejarah telah memengaruhi apa yang orang pikir mereka ketahui.

    Dalam penelitian itu, orang diminta untuk mengisi kuesioner yang menguji pengetahuan mereka tentang fakta medis tentang orang kulit hitam dan orang kulit putih, beberapa di antaranya terkait dengan rasa sakit.

    “Orang-orang tidak tahu apa-apa,” kata Dr. Mays. “Sungguh menakjubkan jenis pengetahuan yang tidak mereka miliki.”

    Penulis studi Dartmouth baru menyarankan stereotip yang didiskreditkan mungkin juga menghalangi pereda nyeri yang efektif untuk pasien kulit hitam.

    Dr. Green melaporkan, “Satu studi menemukan bahwa peserta pelatihan medis yang mempercayai stereotip palsu tentang pasien kulit hitam (misalnya, bahwa mereka secara biologis berbeda dari pasien kulit putih) memberikan penilaian nyeri yang lebih tidak akurat dan melakukan pekerjaan yang lebih buruk dalam membuat rekomendasi pengobatan.”

    “Menarik karena saya mengajar mata kuliah disparitas kesehatan,” kata Dr. Mays.

    “Saya memiliki dokter dalam kursus saya, perawat dalam kursus saya, saya memiliki siswa reguler di kursus saya, dan saya mengajar dengan cara yang sangat spesifik karena saya tidak ingin orang pergi dengan stereotip.”

    Jika pengasuh telah diajari nilai menjadi lebih bijaksana dalam interaksi mereka dengan pasien, Dr. Mays menegaskan, “Anda memiliki pemahaman yang lebih baik tentang solusi intervensi.”

    Dr. Mays juga mencatat kemungkinan batu sandungan lainnya.

    Harapan yang lebih rendah dapat berarti bahwa pasien kulit hitam “tidak menilai kesehatan mereka seburuk yang sebenarnya,” terutama dibandingkan dengan orang lain yang mereka kenal.

    Berita Kesehatan 2021: Perbedaan Dosis Obat Pada Pasien

    Pasien kulit putih, di sisi lain, mungkin “merasa mereka memiliki hak, dan menuntut untuk mendapatkan pengobatan karena mereka sudah terbiasa.”

    Oleh karena itu, kata Dr. Mays, “Ini benar-benar dua hal: Kemampuan untuk menunjukkan [cara sesuatu menyakitkan], dan kemampuan [dokter] untuk mendengar berdasarkan cara penyajiannya.”

    Ini terkait dengan saran penelitian bahwa “ketidaksesuaian rasial pasien-dokter” juga dapat menjadi faktor, dengan “potensi tingkat empati, kepercayaan, persepsi dokter tentang rasa sakit pasien yang lebih rendah, dan komunikasi yang efektif.”…

  • Berita Kesehatan 2021: Minyak Esensial Dapat Obati Parkinson
    Billygordon

    Berita Kesehatan 2021: Minyak Esensial Dapat Obati Parkinson

    Berita Kesehatan 2021: Minyak Esensial Dapat Obati Parkinson – Hilangnya saraf penghasil dopamin secara progresif di otak menyebabkan kesulitan dengan gerakan dan kognisi yang menjadi ciri penyakit Parkinson.

    Sebuah penelitian telah menemukan bahwa farnesol, yang digunakan orang dalam wewangian dan merupakan komponen dari banyak minyak esensial, mempertahankan saraf dopamin pada model tikus Parkinson. sbobetasia

    Para peneliti belum menentukan keamanan dan kemanjuran farnesol sebagai pengobatan pada manusia.

    Berita Kesehatan 2021: Minyak Esensial Dapat Obati Parkinson

    Pada Parkinson, neuron penghasil dopamin (saraf) di bagian otak yang disebut substantia nigra secara progresif mati

    Neuron dopamin sangat penting untuk gerakan dan kognisi, sehingga hilangnya secara bertahap selama beberapa tahun menyebabkan gejala yang memburuk, seperti tremor, kekakuan otot, kesulitan berjalan, dan demensia.

    Saat ini tidak ada terapi yang terbukti untuk menunda atau mencegah perkembangan Parkinson.

    Obat-obatan seperti L-DOPA meningkatkan kadar dopamin di otak dan meningkatkan sinyal saraf dopamin, yang membantu meringankan gejala motorik.

    Namun, perawatan ini tidak memperlambat hilangnya saraf dopamin secara progresif.

    Jadi penemuan senyawa yang mencegah kematian neuron dopamin pada model tikus dengan penyakit Parkinson dapat menjadi langkah perubahan dalam pengobatan.

    Senyawa yang disebut farnesol, terjadi secara alami pada tumbuhan dan merupakan komponen dari beberapa minyak esensial, termasuk serai, serai, dan balsam.

    Ini telah lama ditampilkan sebagai bahan dalam pembuatan parfum. Senyawa ini juga tersebar luas di jaringan hewan.

    “Parkinson adalah apa yang terjadi ketika sel-sel penghasil dopamin di otak mati, jadi penelitian ini penting karena menyoroti jalur baru yang dapat menargetkan dan melindungi sel-sel otak ini pada seseorang dengan Parkinson,” kata Prof. David Dexter, Ph.D, direktur asosiasi penelitian di badan amal Parkinson’s UK, yang tidak terlibat dalam penelitian ini.

    Hampir 1 juta orang di Amerika Serikat dan lebih dari 10 juta di seluruh dunia hidup dengan penyakit Parkinson.

    Ini adalah kondisi neurologis yang tumbuh paling cepat di dunia.

    “[T]dia membutuhkan pengobatan baru [yang] dapat memperlambat atau menghentikan Parkinson di jalurnya tidak pernah lebih mendesak,” Prof. Dexter mengatakan kepada Medical News Today.

    “Merancang obat yang lebih kuat yang mereplikasi aksi senyawa alami ini – farnesol – akan menjadi langkah selanjutnya bagi para peneliti untuk mengembangkan ini ke dalam uji klinis dan berpotensi memegang kunci untuk pengobatan baru yang inovatif,” katanya.

    Penelitian baru, yang dipimpin oleh para ilmuwan di Sungkyunkwan University School of Medicine di Suwon, Korea Selatan, dan Johns Hopkins University School of Medicine di Baltimore, MD, muncul di Science Translational Medicine.

    Tujuan PARIS

    Para peneliti mulai dengan menyaring perpustakaan besar obat untuk menemukan senyawa yang menghambat protein yang disebut PARIS, yang terlibat dalam kematian neuron dopamin di Parkinson.

    PARIS memperlambat pembuatan protein lain, PGC-1 alpha, yang melindungi sel-sel otak dari molekul oksigen yang sangat reaktif.

    Jika tingkat alfa PGC-1 rendah, molekul reaktif akhirnya membunuh sel.

    Proses penyaringan mengidentifikasi farnesol sebagai penghambat PARIS yang kuat.

    Yang penting, orang dapat meminum obat tersebut secara oral, dan obat tersebut dapat melewati sawar darah otak untuk melindungi sel-sel otak.

    Farnesol secara kimiawi mengubah PARIS dalam proses yang dikenal sebagai farnesylation.

    Para peneliti tertarik untuk menemukan dari studi postmortem bahwa tingkat farnesylated PARIS lebih rendah di substansia nigra orang dengan Parkison dibandingkan dengan kontrol.

    Temuan ini menunjukkan bahwa pengurangan farnesilasi PARIS berkontribusi pada kematian neuron dopamin di Parkinson.

    Untuk menyelidiki apakah farnesol dapat melindungi neuron, para peneliti memberi makan tikus baik diet biasa yang dilengkapi dengan farnesol atau diet biasa saja selama 1 minggu.

    Mereka kemudian menyuntikkan fibril dari protein yang salah lipatan yang disebut alpha-synuclein – ciri khas Parkinson – ke dalam otak hewan.

    Berita Kesehatan 2021: Minyak Esensial Dapat Obati Parkinson

    Tikus-tikus yang makan makanan yang dilengkapi dengan farnesol menunjukkan hasil dua kali lebih baik pada tes standar kekuatan dan koordinasi dibandingkan dengan tikus yang makan makanan biasa.

    Para peneliti kemudian menemukan bahwa tikus yang menjalani diet farnesol memiliki dua kali lebih banyak neuron dopamin sehat di otak mereka.

    Otak tikus yang makan makanan normal mengandung sekitar 55% lebih sedikit protein pelindung PGC-1 alfa dibandingkan tikus yang diberi makanan tambahan farnesol.…

  • Berita Kesehatan 2021: Diet Bebas Gluten Redakan Nyeri Haid?
    Billygordon

    Berita Kesehatan 2021: Diet Bebas Gluten Redakan Nyeri Haid?

    Berita Kesehatan 2021: Diet Bebas Gluten Redakan Nyeri Haid? – Nyeri haid menyebabkan penderitaan bulanan bagi banyak orang. Meskipun penghilang rasa sakit dan perawatan hormonal bisa efektif, mereka sering memiliki efek samping yang tidak diinginkan.

    Bukti anekdotal menunjukkan bahwa perubahan pola makan untuk mengurangi asupan makanan yang mengandung gluten mungkin menjadi jawaban bagi sebagian orang. sbobetmobile

    Medical News Today berbicara dengan wanita muda yang telah mencoba pendekatan ini, dan kami juga mengeksplorasi sains di balik klaim tersebut.

    Berita Kesehatan 2021: Diet Bebas Gluten Redakan Nyeri Haid?

    “Saya akan dibangunkan oleh perasaan kram di perut bagian bawah, jadi saya akan segera bangun dan meminum [obat pereda nyeri].”

    “Tetapi sebelum mereka mulai bekerja, saya akan berbaring di lantai dengan kram yang menyiksa menyebar di kaki dan punggung saya, gemetar, berkeringat, dan berusaha untuk tidak muntah. Lalu aku akan musnah sepanjang sisa hari ini.”

    Cobaan bulanan Eve yang berusia delapan belas tahun akan akrab bagi banyak remaja putri. Lebih dari 80% wanita mengalami rasa sakit saat menstruasi, dan hampir 20% wanita, rasa sakitnya cukup buruk untuk memengaruhi kehidupan sehari-hari mereka.

    Kabar baiknya adalah bahwa nyeri haid umumnya berkurang seiring bertambahnya usia, dan banyak orang yang mengalami menstruasi mendapati bahwa nyeri haid berkurang setelah memiliki anak.

    Menurut Dr. Polly Cohen, yang berspesialisasi dalam kesehatan wanita, bahwa 20% hampir pasti merupakan perkiraan yang terlalu rendah: “Nyeri haid jelas tidak dilaporkan.”

    “Kebanyakan wanita berpikir itu adalah bagian normal dari menjadi wanita, jadi tahan saja atau cari di internet cara untuk mengatasinya daripada pergi ke dokter mereka.”

    Mengapa menstruasi terasa sakit?

    Kurang dari 2% mamalia mengalami menstruasi — manusia, beberapa monyet dan kelelawar, dan bahkan tikus kecil berduri, yang kebetulan juga mengalami sindrom pra-menstruasi.

    Kesamaan mereka adalah bahwa mereka berinvestasi banyak dalam kehamilan hanya untuk satu atau dua bayi.

    Saat embrio berkembang, ia mendapatkan semua nutrisinya melalui plasenta, yang menempel pada dinding rahim ibu.

    Lapisan tebal yang terbentuk selama siklus menstruasi menghentikan plasenta yang menyebabkan kerusakan permanen pada dinding rahim.

    Jika sel telur tidak dibuahi, lapisan itu rusak dan terlepas, dan lapisan baru tumbuh untuk mempersiapkan kesempatan kehamilan berikutnya.

    Itulah sebabnya beberapa mamalia mengalami menstruasi, proses di mana jaringan endometrium yang “tidak terpakai” ini dikeluarkan dari tubuh.

    “Rasa sakitnya berasal dari respons peradangan saat lapisan rahim terlepas,” kata Sally King of Menstrual Matters, pusat informasi online nirlaba, kepada MNT.

    “Ketika sel-sel lapisan ditumpahkan, pembuluh darah di rahim pecah, itulah sebabnya darah hilang bersama sel-sel itu,” jelasnya.

    Sebelum zaman modern, wanita tidak mengalami banyak menstruasi, karena kemungkinan besar mereka menghabiskan sebagian besar masa dewasanya untuk hamil atau menyusui.

    Oleh karena itu, mereka mungkin hanya memiliki sekitar 100 periode dalam hidup mereka.

    Sekarang, sebagian besar memiliki lebih dari 400 periode antara pubertas dan menopause.

    Jika ini menyebabkan rasa sakit yang serius setiap bulan, itu dapat berdampak nyata pada kehidupan mereka.

    “Masalahnya adalah bahwa menstruasi selalu menjadi hal yang tabu,” Dr. Cohen juga memberi tahu kami. “Kita perlu membuat orang membicarakannya.”

    Pengobatan nyeri haid

    “Bagi dokter, mengobati nyeri haid biasanya trial and error,” kata Dr. Cohen.

    “Untuk memulainya, kita perlu mencari tahu apakah itu nyeri primer, yang tidak memiliki penyebab klinis yang jelas, atau nyeri sekunder, di mana ada kondisi yang mendasarinya, seperti endometriosis atau fibroid, yang memerlukan perawatan.”

    “Untuk nyeri primer, kita mulai dengan parasetamol [acetaminophen]. Jika itu tidak membantu, kami beralih ke obat antiinflamasi nonsteroid (NSAID) – ibuprofen, kemudian asam mefenamat,” tambahnya.

    Bagi sebagian orang, ini bekerja dengan baik, tetapi itu bukan solusi jangka panjang.

    “Mengkonsumsi NSAID untuk waktu yang lama dapat menyebabkan masalah perut seperti maag, jadi kami kemudian beralih ke kontrol hormonal – pil atau koil KB – yang dapat bekerja dengan baik untuk beberapa wanita,” jelas Dr. Cohen.

    Tetapi bagaimana jika Anda telah mencoba semua ini dan, tetap saja, tidak ada yang berhasil?

    Berita Kesehatan 2021: Diet Bebas Gluten Redakan Nyeri Haid?

    Eve memberi tahu MNT bahwa dia telah beralih dari acetaminophen melalui beberapa NSAID ke pil KB:

    “[Penghilang rasa sakit] butuh beberapa saat untuk mulai bekerja, jadi kecuali Anda tahu kapan rasa sakit itu akan menyerang, Anda akan mengalami sekitar setengah jam penderitaan sampai mereka menendang, yang kemudian membuat Anda kelelahan sepanjang hari.”

    “Pil KB tidak berpengaruh pada nyeri haid saya. Saya benar-benar tidak tahu apa yang harus saya coba selanjutnya.”…